English: High magnification micrograph of crypt branching in a case of Crohn's disease with active inflammation. H&E stain. Colonic biopsy of the mucosa.

The micrograph show numerous eosinophils. This suggest an infectious cause and/or inflammatory cause.

The findings in this image (alone) are not diagnostic for Crohn's disease.

Crypt branching is a sign of a chronic crypt destructive process. Causes of chronic crypt destruction that lead to crypt branching include:

• Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease),
• Persistent infectious colitides, and
• Ischemic colitis.

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  High mag.
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  Intermed. mag.