مضاد اللوكوترين

Antileukotrienes
Antileukotrienes
صنف دوائي
معرفات الصنيف
آلية العمل	· مثبط إنزيم; · مناهضة (أدوية)
المستهدف الحيوي	· Enzymes: أركيدونات 5-أكسيجيناز شحمية; FLAP; · Receptors: CysLTRs
	في ويكي بيانات

مضاد اللوكوترين هو دواء يعمل كمثبط للإنزيمات المتعلّقة باللوكوترين (أراخيدونات 5-ليبوأكسيجيناز) أو كمضاد لمستقبلات اللوكوترين (مستقبلات السيستنيل لوكوترين)، ومن هنا تعارض وظيفة وسطاء الالتهاب. ينتج الجهاز المناعي اللوكوترينات والتي تعمل على تشجيع تضيّق القصبات الهوائية، الالتهاب، نفاذية الأوعية الدموية الدقيقة، وإفراز المخاط في الربو ومرض الانسداد الرئوي المزمن.^[1] في بعض الأحيان يُشار بالعامية إلى مضادات مستقبلات اللوكوترين بالاسم لوكاست.

توجّهات

هناك نوعان من التوجّهات لإثباط عمل اللوكوترينات.^[1]

تثبيط مسار الـ 5-ليبوأكسجيناز

تثبط الأدوية التي تثبط إنزيم الـ 5-ليبوأكسجيناز المسار الاصطناعي لأيض اللوكترينات.^[2]^[3]

انظر أيضًا

مضاد الهستامين

المراجع

^ ^ا ^ب Scott JP, Peters-Golden M (سبتمبر 2013). "Antileukotriene agents for the treatment of lung disease". Am. J. Respir. Crit. Care Med. ج. 188 ع. 5: 538–544. DOI:10.1164/rccm.201301-0023PP. PMID:23822826.
^ "Zyflo (Zileuton tablets)" (PDF). United States Food and Drug Administration. Cornerstone Therapeutics Inc. يونيو 2012. ص. 1. مؤرشف من الأصل (PDF) في 2019-03-12. اطلع عليه بتاريخ 2014-12-12. Zileuton is a specific inhibitor of 5-lipoxygenase and thus inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Sulfido-peptide leukotrienes (LTC4, LTD4, LTE4, also known as the slow-releasing substances of anaphylaxis) and LTB4, a chemoattractant for neutrophils and eosinophils, can be measured in a number of biological fluids including bronchoalveolar lavage fluid (BALF) from asthmatic patients.
^ "Enzymes". Hyperforin. 3.6. University of Alberta. 30 يونيو 2013. اطلع عليه بتاريخ 2014-12-12. Hyperforin is found in alcoholic beverages. Hyperforin is a constituent of Hypericum perforatum (St John's Wort) Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). The structure of hyperforin was elucidated by a research group from the Shemyakin Institute of Bio-organic Chemistry (USSR Academy of Sciences in Moscow) and published in 1975. Hyperforin is a prenylated phloroglucinol derivative. Total synthesis of hyperforin has not yet been accomplished, despite attempts by several research groups. Hyperforin has been shown to exhibit anti-inflammatory, anti-tumor, antibiotic and anti-depressant functions (ببمد: 17696442 , 21751836 , 12725578 , 12018529 )
1. Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes ...
2. Prostaglandin G/H synthase 1 ... General function: Involved in peroxidase activity {{استشهاد بموسوعة}}: |موقع= تُجوهل (مساعدة) وروابط خارجية في |اقتباس= (مساعدة)

هذه بذرة مقالة عن الصيدلة بحاجة للتوسيع. فضلًا شارك في تحريرها.

[Antileukotriene-1] ا ^ب Scott JP, Peters-Golden M (سبتمبر 2013). "Antileukotriene agents for the treatment of lung disease". Am. J. Respir. Crit. Care Med. ج. 188 ع. 5: 538–544. DOI:10.1164/rccm.201301-0023PP. PMID:23822826.

[USFDA_Zileuton-2] "Zyflo (Zileuton tablets)" (PDF). United States Food and Drug Administration. Cornerstone Therapeutics Inc. يونيو 2012. ص. 1. مؤرشف من الأصل (PDF) في 2019-03-12. اطلع عليه بتاريخ 2014-12-12. Zileuton is a specific inhibitor of 5-lipoxygenase and thus inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Sulfido-peptide leukotrienes (LTC4, LTD4, LTE4, also known as the slow-releasing substances of anaphylaxis) and LTB4, a chemoattractant for neutrophils and eosinophils, can be measured in a number of biological fluids including bronchoalveolar lavage fluid (BALF) from asthmatic patients.

[Hyperforin_HMDB_5-LOX_COX1-3] "Enzymes". Hyperforin. 3.6. University of Alberta. 30 يونيو 2013. اطلع عليه بتاريخ 2014-12-12. Hyperforin is found in alcoholic beverages. Hyperforin is a constituent of Hypericum perforatum (St John's Wort) Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). The structure of hyperforin was elucidated by a research group from the Shemyakin Institute of Bio-organic Chemistry (USSR Academy of Sciences in Moscow) and published in 1975. Hyperforin is a prenylated phloroglucinol derivative. Total synthesis of hyperforin has not yet been accomplished, despite attempts by several research groups. Hyperforin has been shown to exhibit anti-inflammatory, anti-tumor, antibiotic and anti-depressant functions (ببمد: 17696442 , 21751836 , 12725578 , 12018529 )
1. Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes ...
2. Prostaglandin G/H synthase 1 ... General function: Involved in peroxidase activity {{استشهاد بموسوعة}}: |موقع= تُجوهل (مساعدة) وروابط خارجية في |اقتباس= (مساعدة)

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