MX1

MX dynamin like GTPase 1
معرفات
أسماء بديلة	interferon-induced protein p78, myxoma resistance protein 1, Myxovirus resistance protein 1, interferon-regulated resistance GTP-binding protein MxA, IFI-78K, interferon-inducible protein p78, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78, MX1, interferon-induced GTP-binding protein Mx1
معرفات خارجية
تماثلات متسلسلة
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

MX1‏ (MX dynamin like GTPase 1) هوَ بروتين يُشَفر بواسطة جين MX1 في الإنسان.^[1]^[2]

الوظيفة[عدل]

الأهمية السريرية[عدل]

المراجع[عدل]

^ "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". مؤرشف من الأصل في 2010-12-05.
^ Haller O، Staeheli P، Kochs G (يوليو 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. ج. 89 ع. 6–7: 812–8. DOI:10.1016/j.biochi.2007.04.015. PMID:17570575.

قراءة متعمقة[عدل]

Pavlovic J، Haller O، Staeheli P (1992). "Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle". J. Virol. ج. 66 ع. 4: 2564–9. PMC:289059. PMID:1548781.
Horisberger MA (1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". J. Virol. ج. 66 ع. 8: 4705–9. PMC:241296. PMID:1629950.
Petersen MB، Slaugenhaupt SA، Lewis JG، وآخرون (1991). "A genetic linkage map of 27 markers on human chromosome 21". Genomics. ج. 9 ع. 3: 407–19. DOI:10.1016/0888-7543(91)90406-5. PMID:1674496.
Horisberger MA، McMaster GK، Zeller H، وآخرون (1990). "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter". J. Virol. ج. 64 ع. 3: 1171–81. PMC:249231. PMID:2154602.
Pavlovic J، Zürcher T، Haller O، Staeheli P (1990). "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". J. Virol. ج. 64 ع. 7: 3370–5. PMC:249583. PMID:2161946.
Aebi M، Fäh J، Hurt N، وآخرون (1990). "cDNA structures and regulation of two interferon-induced human Mx proteins". Mol. Cell. Biol. ج. 9 ع. 11: 5062–72. PMC:363658. PMID:2481229.
Weitz G، Bekisz J، Zoon K، Arnheiter H (1990). "Purification and characterization of a human Mx protein". J. Interferon Res. ج. 9 ع. 6: 679–89. DOI:10.1089/jir.1989.9.679. PMID:2607176.
Maruyama K، Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. ج. 138 ع. 1–2: 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID:8125298.
Melén K، Keskinen P، Ronni T، وآخرون (1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope". J. Biol. Chem. ج. 271 ع. 38: 23478–86. DOI:10.1074/jbc.271.38.23478. PMID:8798556.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Ponten A، Sick C، Weeber M، وآخرون (1997). "Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity". J. Virol. ج. 71 ع. 4: 2591–9. PMC:191379. PMID:9060610.
Fernández M، Quiroga JA، Martín J، وآخرون (1997). "Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection". J. Med. Virol. ج. 51 ع. 4: 332–7. DOI:10.1002/(SICI)1096-9071(199704)51:4<332::AID-JMV12>3.0.CO;2-K. PMID:9093949.
Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، وآخرون (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
Li Y، Youssoufian H (1998). "MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups". J. Clin. Invest. ج. 100 ع. 11: 2873–80. DOI:10.1172/JCI119836. PMC:508494. PMID:9389754.
Kochs G، Trost M، Janzen C، Haller O (1998). "MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures". Methods. ج. 15 ع. 3: 255–63. DOI:10.1006/meth.1998.0629. PMID:9735310.
Weber F، Haller O، Kochs G (2000). "MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes". J. Virol. ج. 74 ع. 1: 560–3. DOI:10.1128/JVI.74.1.560-563.2000. PMC:111572. PMID:10590150.
Hattori M، Fujiyama A، Taylor TD، وآخرون (2000). "The DNA sequence of human chromosome 21". Nature. ج. 405 ع. 6784: 311–9. DOI:10.1038/35012518. PMID:10830953.
Hijikata M، Ohta Y، Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon". Intervirology. ج. 43 ع. 2: 124–7. DOI:10.1159/000025035. PMID:10971132.
Engelhardt OG، Ullrich E، Kochs G، Haller O (2002). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies". Exp. Cell Res. ج. 271 ع. 2: 286–95. DOI:10.1006/excr.2001.5380. PMID:11716541.
Hijikata M، Mishiro S، Miyamoto C، وآخرون (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro". Intervirology. ج. 44 ع. 6: 379–82. DOI:10.1159/000050075. PMID:11805446.
Kochs G، Haener M، Aebi U، Haller O (2002). "Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers". J. Biol. Chem. ج. 277 ع. 16: 14172–6. DOI:10.1074/jbc.M200244200. PMID:11847228.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)

هذه بذرة مقالة عن بروتين بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". مؤرشف من الأصل في 2010-12-05.

[pmid17570575-2] Haller O، Staeheli P، Kochs G (يوليو 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. ج. 89 ع. 6–7: 812–8. DOI:10.1016/j.biochi.2007.04.015. PMID:17570575.

[1]

[2]